Dexamethasome-cyclophosphamide pulse therapy for systemic sclerosis

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Systemic sclerosis and dexamethasone cyclophosphamide pulse therapy.

Sir, There have been quite a few instances where the physician or may be even a dermatologist (mis) advices a patient having systemic sclerosis that there is no satisfactory treatment for this disease, as has also been done in the paper ‘Therapeutic trials for systemic sclerosis: An update’ by Sardana and Garg.[1] Such patients often feel frustrated and disappointed, till another dermatologist ...

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Successful use of intravenous cyclophosphamide pulse therapy for interstitial lung disease in a patient with systemic sclerosis on hemodialysis.

Interstitial lung disease and scleroderma renal crisis are major complications of systemic sclerosis, which occasionally coexist in patients with the diffuse cutaneous subtype. We herein report a case of diffuse cutaneous systemic sclerosis under hemodialysis due to a previous history of scleroderma renal crisis, whose interstitial lung disease was effectively and safely treated with a half dos...

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[Cyclophosphamide pulse therapy for refractory rheumatic diseases].

We studied the efficacy of cyclophosphamide pulse therapy (CYP) for refractory rheumatic diseases except for lupus nephritis. Thirty-five patients were included in all, that is 9 patients with systemic lupus erythematosus (SLE), 10 with rheumatoid arthritis (RA), 7 with polymyositis/dermatomyositis (PM/DM), 2 with progressive systemic sclerosis (PSS), 2 with anti-phospholipid antibody syndrome ...

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Cyclophosphamide in systemic sclerosis: light and shadows.

© Copyright CLINICALAND EXPERIMENTAL RHEUMATOLOGY 2004. Pulmonary interstitial fibrosis (PIF) affects half of all patients with systemic sclerosis (SSc) (1) and accounts for one-third of SSc-related deaths (2). Despite enormous efforts, therapy remains empirical and its efficacy is questionable. D-penicillamine (3) interfero n -γ (4), and cyclophosphamide (5) have been used to halt the progress...

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Intravenous Cyclophosphamide Pulse Therapy in the Treatment of Systemic Sclerosis-Related Interstitial Lung Disease: A Long Term Study

OBJECTIVE Interstitial lung disease (ILD) frequently complicates systemic sclerosis (SSc). Cyclophosphamide (CYC) is a promising immunosuppressive therapy for SSc-related ILD. Our objective was to investigate the effectiveness of an intravenous CYC (iv CYC) pulse regime in SSc-related ILD during treatment and thereafter. METHODS In a prospective observational study ten consecutive patients wi...

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ژورنال

عنوان ژورنال: Indian Journal of Dermatology, Venereology and Leprology

سال: 2009

ISSN: 0378-6323

DOI: 10.4103/0378-6323.55400